Acid Suppressive Medication May Increase Risk of Pneumonia

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Acid-suppressive medication use and the risk for hospital-acquired pneumonia.

CONTEXT The use of acid-suppressive medication has been steadily increasing, particularly in the inpatient setting, despite lack of an accepted indication in the majority of these patients. OBJECTIVE To examine the association between acid-suppressive medication and hospital-acquired pneumonia. DESIGN, SETTING, AND PATIENTS Prospective pharmacoepidemiologic cohort study. All patients who we...

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Risk of Stroke-Associated Pneumonia With Acid-Suppressive Drugs

Acid-suppressive drugs, including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), are common medications used for treating upper gastrointestinal tract disorders. However, acid-suppressive drugs have been reported to increase the risk of pneumonia in numerous disease populations. However, the relationship between acid-suppressive drugs and stroke-associated pneumonia...

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Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.

CONTEXT Reduction of gastric acid secretion by acid-suppressive therapy allows pathogen colonization from the upper gastrointestinal tract. The bacteria and viruses in the contaminated stomach have been identified as species from the oral cavity. OBJECTIVE To examine the association between the use of acid-suppressive drugs and occurrence of community-acquired pneumonia. DESIGN, SETTING, AN...

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Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis.

BACKGROUND Observational studies and randomized controlled trials have yielded inconsistent findings about the association between the use of acid-suppressive drugs and the risk of pneumonia. We performed a systematic review and meta-analysis to summarize this association. METHODS We searched three electronic databases (MEDLINE [PubMed], Embase and the Cochrane Library) from inception to Aug....

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Use of acid-suppressive drugs and risk of pneumonia: systematic review and meta-analysis

CMAJ © 2010 Canadian Medical Association or its licensors 1 Recently, the medical literature has paid considerable attention to unrecognized adverse effects of commonly used medications and their potential public health impact. One group of medications in widespread use is acid-suppressive drugs, which represent the second leading category of medication worldwide, with sales totalling US$26.9 b...

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ژورنال

عنوان ژورنال: Journal of Medical Sciences

سال: 2011

ISSN: 1682-4474

DOI: 10.3923/jms.2011.310.310